WDR4

Entrez Summary: N/A
UniProt Summary: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. {ECO:0000255|HAMAP-Rule:MF_03056, ECO:0000269|PubMed:12403464}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifurtimox 1μM R03 exp141	-1.75
CB-5083 0.4μM R08 exp468	1.87
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.93
Citral 75μM R06 exp275	1.98
Salubrinal 20μM R07 exp399	2.03

Global Fraction of Cell Lines Where Essential: 25/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	6/22
urinary tract	3/29
uterus	0/5

Expression Distribution

tRNA methyltransferase complex
tRNA (guanine-N7)-methylation
tRNA (guanine-N7-)-methyltransferase activity
RNA (guanine-N7)-methylation
tRNA methylation
RNA methylation
tRNA modification
tRNA processing
RNA modification
tRNA metabolic process
macromolecule methylation
methylation
ncRNA processing
ncRNA metabolic process
RNA processing
RNA metabolic process
gene expression