ZNF274

Entrez Summary: N/A
UniProt Summary: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin- modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000269|PubMed:10777669, ECO:0000269|PubMed:27029610}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

Screen	Score
Prochlorperazine 5.2μM R02 exp77	-1.89
Menadione 5μM R06 exp292	-1.74

regulation of histone H3-K9 trimethylation
regulation of histone H3-K9 methylation
regulation of histone methylation
regulation of histone modification
regulation of chromatin organization
transcription corepressor activity
regulation of chromosome organization
chromatin binding
sequence-specific DNA binding
DNA-binding transcription factor activity
nucleolus
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
regulation of organelle organization
negative regulation of RNA metabolic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of protein modification process