ZP2

Entrez Summary: N/A
UniProt Summary: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. {ECO:0000250|UniProtKB:P20239}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

prevention of polyspermy
acrosin binding
egg activation
negative regulation of fertilization
regulation of acrosome reaction
regulation of fertilization
multivesicular body
binding of sperm to zona pellucida
coreceptor activity
sperm-egg recognition
negative regulation of reproductive process
cell-cell recognition
single fertilization
regulation of reproductive process
fertilization
negative regulation of multi-organism process
cell recognition
collagen-containing extracellular matrix
regulation of multi-organism process
sexual reproduction
multi-organism reproductive process
endoplasmic reticulum
identical protein binding
cell activation
reproductive process
reproduction
extracellular region