PMP22

Entrez Summary: This gene encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Studies suggest two alternately used promoters drive tissue-specific expression. Various mutations of this gene are causes of Charcot-Marie-Tooth disease Type IA, Dejerine-Sottas syndrome, and hereditary neuropathy with liability to pressure palsies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
UniProt Summary: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

compact myelin
bleb assembly
myelin assembly
peripheral nervous system development
cellular component assembly involved in morphogenesis
myelination
axon ensheathment
ensheathment of neurons
bicellular tight junction
negative regulation of neuron projection development
negative regulation of cell projection organization
negative regulation of neuron differentiation
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
plasma membrane bounded cell projection assembly
cell projection assembly
synaptic signaling
regulation of neuron projection development
regulation of neuron differentiation
negative regulation of cell population proliferation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
regulation of neurogenesis
cellular component morphogenesis
anatomical structure formation involved in morphogenesis
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
cell death
cell-cell signaling
plasma membrane bounded cell projection organization
cell projection organization
negative regulation of multicellular organismal process
generation of neurons