PPP2R5B

Gene Information

Official Symbol: PPP2R5B
Official Name: protein phosphatase 2 regulatory subunit B'beta
Aliases and Previous Symbols: N/A
Entrez ID: 5526
UniProt: Q15173
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008].
UniProt Summary: As the regulatory component of the serine/threonine- protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000269|PubMed:21329884}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2868
Expression level (log2 read counts): 2.5

Expression Distribution

Screen	Score
HMS-I2 1μM R06 exp286	1.76
NFN1 0.4μM R03 exp99	2.04

positive regulation of neurotrophin TRK receptor signaling pathway
protein phosphatase activator activity
regulation of neurotrophin TRK receptor signaling pathway
protein phosphatase type 2A complex
protein phosphatase regulator activity
negative regulation of G0 to G1 transition
regulation of G0 to G1 transition
negative regulation of protein kinase B signaling
regulation of protein autophosphorylation
IRE1-mediated unfolded protein response
positive regulation of cell cycle arrest
endoplasmic reticulum unfolded protein response
regulation of cell cycle arrest
regulation of phosphoprotein phosphatase activity
regulation of phosphatidylinositol 3-kinase signaling
cellular response to unfolded protein
regulation of protein dephosphorylation
cellular response to topologically incorrect protein
response to unfolded protein
regulation of signaling receptor activity
regulation of phosphatase activity
response to topologically incorrect protein
regulation of dephosphorylation
protein dephosphorylation
regulation of protein kinase B signaling
positive regulation of protein complex assembly
regulation of peptidyl-tyrosine phosphorylation
response to endoplasmic reticulum stress
positive regulation of DNA-binding transcription factor activity
regulation of cellular response to growth factor stimulus
positive regulation of neuron projection development
positive regulation of cell cycle process
dephosphorylation
negative regulation of cell cycle process
positive regulation of neuron differentiation
positive regulation of cell cycle
positive regulation of cell projection organization
regulation of DNA-binding transcription factor activity
regulation of protein complex assembly
positive regulation of neurogenesis