PRR7

Gene Information

Official Symbol: PRR7
Official Name: proline rich 7, synaptic
Aliases and Previous Symbols: N/A
Entrez ID: 80758
UniProt: Q8TB68
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222). {ECO:0000250|UniProtKB:P0C6T3, ECO:0000250|UniProtKB:Q3V0I2, ECO:0000269|PubMed:21460222, ECO:0000269|PubMed:27458189}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Metformin 100 to 150μM on day4 R04 exp170	-1.85
Cannabidiol 13μM R08 exp465	1.76
UM0129480 7μM R02 exp85	1.77
UM0011500 10μM R05 exp246	1.8
EPZ-5676 30μM R05 exp233	2.12
QNZ 0.01μM R08 exp439	2.27

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12791
Expression level (log2 read counts): 2.86

Expression Distribution

long-chain fatty acid binding
postsynapse to nucleus signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
postsynaptic density, intracellular component
ubiquitin-like protein ligase binding
protein tyrosine kinase binding
postsynaptic signal transduction
negative regulation of protein ubiquitination
negative regulation of protein modification by small protein conjugation or removal
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
T cell differentiation
positive regulation of cysteine-type endopeptidase activity
positive regulation of endopeptidase activity
positive regulation of apoptotic signaling pathway
positive regulation of peptidase activity
postsynaptic membrane
regulation of protein ubiquitination
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of protein modification by small protein conjugation or removal
T cell activation
lymphocyte differentiation
regulation of cysteine-type endopeptidase activity
protein-containing complex binding
leukocyte differentiation
glutamatergic synapse
positive regulation of proteolysis
lymphocyte activation
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
dendrite
regulation of peptidase activity
synaptic signaling
cell junction
hemopoiesis
negative regulation of protein modification process
hematopoietic or lymphoid organ development
adaptive immune response
positive regulation of apoptotic process
positive regulation of programmed cell death