TCP1
Gene Information
- Official Symbol: TCP1
- Official Name: t-complex 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6950
- UniProt: P17987
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.
Pfam Domains GO Terms
Pfam Domains
| Cpn60 TCP1 |
GO Terms
| translocation of peptides or proteins into host cell cytoplasm |
| translocation of peptides or proteins into host |
| translocation of peptides or proteins into other organism involved in symbiotic interaction |
| RNA localization to nucleus |
| scaRNA localization to Cajal body |
| RNA localization to Cajal body |
| zona pellucida receptor complex |
| translocation of molecules into host |
| translocation of molecules into other organism involved in symbiotic interaction |
| regulation of protein localization to Cajal body |
| positive regulation of protein localization to Cajal body |
| tubulin complex assembly |
| regulation of macrophage apoptotic process |
| positive regulation of establishment of protein localization to telomere |
| chaperonin-containing T-complex |
| regulation of establishment of protein localization to telomere |
| positive regulation of protein localization to chromosome, telomeric region |
| regulation of establishment of protein localization to chromosome |
| regulation of protein localization to chromosome, telomeric region |
| positive regulation of telomerase RNA localization to Cajal body |
| regulation of telomerase RNA localization to Cajal body |
| pericentriolar material |
| nuclear heterochromatin |
| regulation of myeloid cell apoptotic process |
| positive regulation of telomere maintenance via telomerase |
| binding of sperm to zona pellucida |
| positive regulation of telomerase activity |
| positive regulation of telomere maintenance via telomere lengthening |
| toxin transport |
| interleukin-12-mediated signaling pathway |
| cellular response to interleukin-12 |
| response to interleukin-12 |
| positive regulation of telomere maintenance |
| regulation of telomerase activity |
| sperm-egg recognition |
| regulation of telomere maintenance via telomerase |
| regulation of telomere maintenance via telomere lengthening |
| positive regulation of DNA biosynthetic process |
| multi-organism localization |
| cell-cell recognition |
| multi-organism transport |
| cell body |
| positive regulation of protein localization to nucleus |
| regulation of telomere maintenance |
| regulation of leukocyte apoptotic process |
| acrosomal vesicle |
| regulation of DNA biosynthetic process |
| regulation of protein localization to nucleus |
| unfolded protein binding |
| single fertilization |
| interaction with host |
| fertilization |
| positive regulation of chromosome organization |
| protein stabilization |
| positive regulation of DNA metabolic process |
| RNA localization |
| protein folding |
| cell recognition |
| regulation of protein stability |
| ubiquitin protein ligase binding |
| microtubule |
| positive regulation of cellular protein localization |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| positive regulation of establishment of protein localization |
| centrosome |
| regulation of cellular protein localization |
| positive regulation of organelle organization |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of establishment of protein localization |
| symbiotic process |
| interspecies interaction between organisms |
| sexual reproduction |
| cellular protein-containing complex assembly |
| regulation of cellular localization |
| regulation of transferase activity |
| Golgi apparatus |
| multi-organism reproductive process |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| response to cytokine |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| RNA binding |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| ATP binding |
| protein transport |
| peptide transport |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| amide transport |
| establishment of protein localization |
| regulation of cell death |
| positive regulation of molecular function |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Etoposide 1μM R00 exp19 | 1.74 |
| Epothilone-B 0.0015μM R05 exp231 | 2.1 |
| SGC0946 7μM R03 exp151 | 2.68 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 731/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 26/28 |
| bone | 26/26 |
| breast | 32/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 15/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 74/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 654
- Expression level (log2 read counts): 8.88
Expression Distribution
TCP1 Expression in NALM6 Cells: 8.88
