TNIP1
Gene Information
- Official Symbol: TNIP1
- Official Name: TNFAIP3 interacting protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 10318
- UniProt: Q15025
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade |
| modulation by symbiont of host signal transduction pathway |
| modulation of signal transduction in other organism involved in symbiotic interaction |
| modulation of signal transduction in other organism |
| positive regulation of protein deubiquitination |
| regulation of protein deubiquitination |
| mitogen-activated protein kinase binding |
| modulation by symbiont of host cellular process |
| polyubiquitin modification-dependent protein binding |
| MyD88-dependent toll-like receptor signaling pathway |
| modification by symbiont of host morphology or physiology |
| negative regulation of I-kappaB kinase/NF-kappaB signaling |
| leukocyte cell-cell adhesion |
| negative regulation of viral genome replication |
| negative regulation of ERK1 and ERK2 cascade |
| negative regulation of viral life cycle |
| regulation of viral genome replication |
| negative regulation of viral process |
| toll-like receptor signaling pathway |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| pattern recognition receptor signaling pathway |
| positive regulation of protein modification by small protein conjugation or removal |
| positive regulation of inflammatory response |
| regulation of viral life cycle |
| modification of morphology or physiology of other organism |
| interaction with host |
| negative regulation of MAPK cascade |
| regulation of viral process |
| negative regulation of multi-organism process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of protein modification by small protein conjugation or removal |
| innate immune response-activating signal transduction |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| activation of innate immune response |
| protein deubiquitination |
| regulation of ERK1 and ERK2 cascade |
| protein modification by small protein removal |
| glycoprotein biosynthetic process |
| regulation of inflammatory response |
| positive regulation of innate immune response |
| positive regulation of proteolysis |
| positive regulation of response to biotic stimulus |
| translation |
| glycoprotein metabolic process |
| negative regulation of protein phosphorylation |
| peptide biosynthetic process |
| negative regulation of phosphorylation |
| regulation of innate immune response |
| positive regulation of defense response |
| inflammatory response |
| cell-cell adhesion |
| negative regulation of intracellular signal transduction |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| amide biosynthetic process |
| peptide metabolic process |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| negative regulation of protein modification process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| carbohydrate derivative biosynthetic process |
| activation of immune response |
| regulation of proteolysis |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of multi-organism process |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| positive regulation of immune response |
| cell adhesion |
| biological adhesion |
| protein modification by small protein conjugation or removal |
| carbohydrate derivative metabolic process |
| negative regulation of cellular protein metabolic process |
| identical protein binding |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| proteolysis |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| organonitrogen compound biosynthetic process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| NFN1 1μM R03 exp100 | -1.94 |
| 4-Nitroquinoline-1-oxide 0.5μM R08 exp446 | -1.76 |
| Vemurafenib 6.6μM R02 exp89 | -1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12120
- Expression level (log2 read counts): 4.67
Expression Distribution
TNIP1 Expression in NALM6 Cells: 4.67
