ABCD2
Gene Information
- Official Symbol: ABCD2
- Official Name: ATP binding cassette subfamily D member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 225
- UniProt: Q9UBJ2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Probable transporter.
Pfam Domains GO Terms
Pfam Domains
| ABC membrane 2 |
| ABC tran |
GO Terms
| very long-chain fatty acid catabolic process |
| positive regulation of unsaturated fatty acid biosynthetic process |
| neuron projection maintenance |
| positive regulation of fatty acid beta-oxidation |
| regulation of unsaturated fatty acid biosynthetic process |
| myelin maintenance |
| positive regulation of fatty acid oxidation |
| negative regulation of cytokine production involved in inflammatory response |
| regulation of fatty acid beta-oxidation |
| positive regulation of fatty acid biosynthetic process |
| positive regulation of lipid catabolic process |
| negative regulation of reactive oxygen species biosynthetic process |
| regulation of fatty acid oxidation |
| very long-chain fatty acid metabolic process |
| positive regulation of fatty acid metabolic process |
| regulation of cytokine production involved in inflammatory response |
| neuron projection organization |
| regulation of fatty acid biosynthetic process |
| ATPase-coupled transmembrane transporter activity |
| negative regulation of reactive oxygen species metabolic process |
| regulation of lipid catabolic process |
| peroxisomal membrane |
| fatty acid beta-oxidation |
| fatty acid oxidation |
| lipid oxidation |
| positive regulation of lipid biosynthetic process |
| regulation of reactive oxygen species biosynthetic process |
| regulation of fatty acid metabolic process |
| plasma membrane organization |
| fatty acid catabolic process |
| myelination |
| peroxisome |
| ensheathment of neurons |
| axon ensheathment |
| monocarboxylic acid catabolic process |
| negative regulation of inflammatory response |
| positive regulation of small molecule metabolic process |
| positive regulation of lipid metabolic process |
| regulation of cellular ketone metabolic process |
| regulation of reactive oxygen species metabolic process |
| regulation of lipid biosynthetic process |
| cellular lipid catabolic process |
| lipid modification |
| negative regulation of defense response |
| ATPase activity |
| carboxylic acid catabolic process |
| organic acid catabolic process |
| negative regulation of cytokine production |
| lipid catabolic process |
| fatty acid metabolic process |
| regulation of inflammatory response |
| negative regulation of response to external stimulus |
| positive regulation of cellular catabolic process |
| regulation of lipid metabolic process |
| endomembrane system organization |
| regulation of small molecule metabolic process |
| positive regulation of catabolic process |
| small molecule catabolic process |
| monocarboxylic acid metabolic process |
| regulation of cytokine production |
| regulation of defense response |
| regulation of cellular catabolic process |
| membrane organization |
| protein homodimerization activity |
| carboxylic acid metabolic process |
| ion transmembrane transport |
| cellular lipid metabolic process |
| oxidation-reduction process |
| regulation of catabolic process |
| oxoacid metabolic process |
| organic acid metabolic process |
| regulation of response to external stimulus |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| transmembrane transport |
| ion transport |
| regulation of response to stress |
| ATP binding |
| negative regulation of biosynthetic process |
| negative regulation of response to stimulus |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UNC1999 2μM R03 exp155 | 1.71 |
| CCCP 1μM R00 exp11 | 1.86 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16766
- Expression level (log2 read counts): -1.76
Expression Distribution
ABCD2 Expression in NALM6 Cells: -1.76
