ACADVL

Entrez Summary: The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons. {ECO:0000269|PubMed:18227065}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

very-long-chain-acyl-CoA dehydrogenase activity
long-chain-acyl-CoA dehydrogenase activity
negative regulation of fatty acid oxidation
fatty acid beta-oxidation using acyl-CoA dehydrogenase
negative regulation of fatty acid biosynthetic process
fatty-acyl-CoA binding
negative regulation of fatty acid metabolic process
temperature homeostasis
regulation of fatty acid oxidation
mitochondrial nucleoid
regulation of fatty acid biosynthetic process
response to cold
negative regulation of lipid biosynthetic process
IRE1-mediated unfolded protein response
regulation of cholesterol metabolic process
fatty acid beta-oxidation
flavin adenine dinucleotide binding
fatty acid oxidation
lipid oxidation
negative regulation of lipid metabolic process
regulation of fatty acid metabolic process
negative regulation of small molecule metabolic process
fatty acid catabolic process
mitochondrial membrane
endoplasmic reticulum unfolded protein response
regulation of steroid metabolic process
monocarboxylic acid catabolic process
cellular response to unfolded protein
cellular response to topologically incorrect protein
response to unfolded protein
regulation of cellular ketone metabolic process
response to temperature stimulus
regulation of lipid biosynthetic process
response to topologically incorrect protein
cellular lipid catabolic process
lipid modification
energy derivation by oxidation of organic compounds
response to endoplasmic reticulum stress
carboxylic acid catabolic process
organic acid catabolic process