ACAN

Entrez Summary: This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

perisynaptic extracellular matrix
keratan sulfate catabolic process
extracellular matrix structural constituent conferring compression resistance
cartilage condensation
cell aggregation
hyaluronic acid binding
keratan sulfate biosynthetic process
keratan sulfate metabolic process
chondrocyte development
collagen fibril organization
sulfur compound catabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
GABA-ergic synapse
proteoglycan biosynthetic process
chondrocyte differentiation
basement membrane
proteoglycan metabolic process
lysosomal lumen
Golgi lumen
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
extracellular matrix structural constituent
glycosaminoglycan metabolic process
aminoglycan metabolic process
cartilage development
carbohydrate binding
sulfur compound biosynthetic process
carbohydrate derivative catabolic process
connective tissue development
extracellular matrix
skeletal system morphogenesis
glycoprotein biosynthetic process
extracellular matrix organization
glutamatergic synapse
collagen-containing extracellular matrix
sulfur compound metabolic process
extracellular structure organization
glycoprotein metabolic process