ACOT13

Entrez Summary: N/A
UniProt Summary: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16934754, ECO:0000269|PubMed:19170545}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acyl-CoA hydrolase activity
negative regulation of cold-induced thermogenesis
protein homotetramerization
acyl-CoA metabolic process
thioester metabolic process
spindle
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
regulation of cold-induced thermogenesis
protein tetramerization
coenzyme metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
protein homooligomerization
sulfur compound metabolic process
purine-containing compound metabolic process
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
protein complex oligomerization
nucleobase-containing small molecule metabolic process
cellular amide metabolic process
organophosphate metabolic process
carbohydrate derivative metabolic process
negative regulation of multicellular organismal process
mitochondrion
protein-containing complex assembly
small molecule metabolic process
protein-containing complex subunit organization