ACOT2

Entrez Summary: N/A
UniProt Summary: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs. {ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

BAAT C
Bile Hydr Trans

myristoyl-CoA hydrolase activity
palmitoyl-CoA hydrolase activity
acyl-CoA hydrolase activity
very long-chain fatty acid metabolic process
carboxylic ester hydrolase activity
peroxisomal matrix
establishment of protein localization to peroxisome
protein localization to peroxisome
protein targeting to peroxisome
peroxisomal transport
peroxisome organization
acyl-CoA metabolic process
thioester metabolic process
long-chain fatty acid metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
coenzyme metabolic process
purine ribonucleotide metabolic process
fatty acid metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
protein targeting
sulfur compound metabolic process
purine-containing compound metabolic process
mitochondrial matrix
establishment of protein localization to organelle
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
monocarboxylic acid metabolic process
nucleobase-containing small molecule metabolic process
protein localization to organelle
cellular amide metabolic process
organophosphate metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
intracellular protein transport
oxoacid metabolic process