ACPL2

Entrez Summary: N/A
UniProt Summary: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1- 4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. {ECO:0000269|PubMed:24425863}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of heparan sulfate proteoglycan biosynthetic process
positive regulation of proteoglycan biosynthetic process
regulation of heparan sulfate proteoglycan biosynthetic process
positive regulation of glycoprotein biosynthetic process
positive regulation of glycoprotein metabolic process
chondroitin sulfate proteoglycan biosynthetic process
regulation of glycoprotein biosynthetic process
chondroitin sulfate proteoglycan metabolic process
regulation of glycoprotein metabolic process
phosphatase activity
proteoglycan biosynthetic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
aminoglycan biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
dephosphorylation
glycoprotein biosynthetic process
glycoprotein metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
Golgi apparatus
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
positive regulation of protein metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of biosynthetic process