ACVR2A [The Human Chemical-Genetic Interaction Map Project]

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======= ACVR2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACVR2A
  * **<color #00a2e8>Official Name</color>**: activin A receptor type 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=92|92]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27037|P27037]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACVR2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACVR2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102581|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity). {ECO:0000250|UniProtKB:P27038, ECO:0000269|PubMed:1314589}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|Activin recp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activin-activated receptor activity|
|penile erection|
|inhibin-betaglycan-ActRII complex|
|Sertoli cell proliferation|
|transforming growth factor beta receptor activity, type II|
|sperm ejaculation|
|inhibin binding|
|activin receptor complex|
|BMP receptor activity|
|positive regulation of activin receptor signaling pathway|
|transmembrane receptor protein serine/threonine kinase activity|
|type I transforming growth factor beta receptor binding|
|insemination|
|activin binding|
|copulation|
|transforming growth factor beta-activated receptor activity|
|activin receptor signaling pathway|
|regulation of activin receptor signaling pathway|
|gastrulation with mouth forming second|
|positive regulation of erythrocyte differentiation|
|growth factor binding|
|mating|
|coreceptor activity|
|positive regulation of bone mineralization|
|regulation of nitric-oxide synthase activity|
|regulation of erythrocyte differentiation|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|SMAD binding|
|regulation of monooxygenase activity|
|protein self-association|
|positive regulation of osteoblast differentiation|
|regulation of pathway-restricted SMAD protein phosphorylation|
|regulation of bone mineralization|
|positive regulation of ossification|
|epithelial cell proliferation|
|PDZ domain binding|
|BMP signaling pathway|
|positive regulation of myeloid cell differentiation|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|regulation of oxidoreductase activity|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|response to BMP|
|cellular response to BMP stimulus|
|regulation of osteoblast differentiation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|mesoderm development|
|specification of symmetry|
|embryonic skeletal system development|
|male gonad development|
|development of primary male sexual characteristics|
|cellular response to transforming growth factor beta stimulus|
|male sex differentiation|
|gastrulation|
|response to transforming growth factor beta|
|positive regulation of hemopoiesis|
|regulation of ossification|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|receptor complex|
|gonad development|
|multi-multicellular organism process|
|development of primary sexual characteristics|
|anterior/posterior pattern specification|
|regulation of myeloid cell differentiation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|sex differentiation|
|regionalization|
|protein serine/threonine kinase activity|
|reproductive structure development|
|reproductive system development|
|pattern specification process|
|regulation of hemopoiesis|
|skeletal system development|
|cellular response to growth factor stimulus|
|response to growth factor|
|spermatogenesis|
|cell population proliferation|
|male gamete generation|
|embryonic morphogenesis|
|cell surface|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of developmental process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.9|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.89|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.76|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.7|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.79|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.81|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.84|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.92|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11050
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACVR2A Expression in NALM6 Cells: 0.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>