ACVR2A
Gene Information
- Official Symbol: ACVR2A
- Official Name: activin A receptor type 2A
- Aliases and Previous Symbols: N/A
- Entrez ID: 92
- UniProt: P27037
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity). {ECO:0000250|UniProtKB:P27038, ECO:0000269|PubMed:1314589}.
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
| Activin recp |
GO Terms
| activin-activated receptor activity |
| penile erection |
| inhibin-betaglycan-ActRII complex |
| Sertoli cell proliferation |
| transforming growth factor beta receptor activity, type II |
| sperm ejaculation |
| inhibin binding |
| activin receptor complex |
| BMP receptor activity |
| positive regulation of activin receptor signaling pathway |
| transmembrane receptor protein serine/threonine kinase activity |
| type I transforming growth factor beta receptor binding |
| insemination |
| activin binding |
| copulation |
| transforming growth factor beta-activated receptor activity |
| activin receptor signaling pathway |
| regulation of activin receptor signaling pathway |
| gastrulation with mouth forming second |
| positive regulation of erythrocyte differentiation |
| growth factor binding |
| mating |
| coreceptor activity |
| positive regulation of bone mineralization |
| regulation of nitric-oxide synthase activity |
| regulation of erythrocyte differentiation |
| positive regulation of biomineralization |
| positive regulation of biomineral tissue development |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| SMAD binding |
| regulation of monooxygenase activity |
| protein self-association |
| positive regulation of osteoblast differentiation |
| regulation of pathway-restricted SMAD protein phosphorylation |
| regulation of bone mineralization |
| positive regulation of ossification |
| epithelial cell proliferation |
| PDZ domain binding |
| BMP signaling pathway |
| positive regulation of myeloid cell differentiation |
| regulation of biomineralization |
| regulation of biomineral tissue development |
| regulation of oxidoreductase activity |
| transforming growth factor beta receptor signaling pathway |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| response to BMP |
| cellular response to BMP stimulus |
| regulation of osteoblast differentiation |
| determination of left/right symmetry |
| determination of bilateral symmetry |
| mesoderm development |
| specification of symmetry |
| embryonic skeletal system development |
| male gonad development |
| development of primary male sexual characteristics |
| cellular response to transforming growth factor beta stimulus |
| male sex differentiation |
| gastrulation |
| response to transforming growth factor beta |
| positive regulation of hemopoiesis |
| regulation of ossification |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| receptor complex |
| gonad development |
| multi-multicellular organism process |
| development of primary sexual characteristics |
| anterior/posterior pattern specification |
| regulation of myeloid cell differentiation |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| sex differentiation |
| regionalization |
| protein serine/threonine kinase activity |
| reproductive structure development |
| reproductive system development |
| pattern specification process |
| regulation of hemopoiesis |
| skeletal system development |
| cellular response to growth factor stimulus |
| response to growth factor |
| spermatogenesis |
| cell population proliferation |
| male gamete generation |
| embryonic morphogenesis |
| cell surface |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| developmental process involved in reproduction |
| gamete generation |
| enzyme linked receptor protein signaling pathway |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| positive regulation of cell differentiation |
| protein phosphorylation |
| embryo development |
| multi-organism reproductive process |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of developmental process |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| ATP binding |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11050
- Expression level (log2 read counts): 0.19
Expression Distribution
ACVR2A Expression in NALM6 Cells: 0.19
