ADAM8
Gene Information
- Official Symbol: ADAM8
- Official Name: ADAM metallopeptidase domain 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 101
- UniProt: P78325
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Possible involvement in extravasation of leukocytes.
Pfam Domains GO Terms
Pfam Domains
| ADAM CR |
| Reprolysin |
| Pep M12B propep |
| Disintegrin |
GO Terms
| alpha9-beta1 integrin-ADAM8 complex |
| regulation of fibronectin-dependent thymocyte migration |
| positive regulation of fibronectin-dependent thymocyte migration |
| positive regulation of tumor necrosis factor (ligand) superfamily member 11 production |
| alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex |
| dense core granule membrane |
| positive regulation of thymocyte migration |
| regulation of tumor necrosis factor (ligand) superfamily member 11 production |
| positive regulation of eosinophil migration |
| phagolysosome |
| tertiary granule |
| regulation of thymocyte migration |
| regulation of eosinophil migration |
| positive regulation of thymocyte apoptotic process |
| positive regulation of neutrophil extravasation |
| regulation of neutrophil extravasation |
| positive regulation of T cell differentiation in thymus |
| regulation of thymocyte apoptotic process |
| specific granule |
| positive regulation of T cell apoptotic process |
| leukocyte migration involved in inflammatory response |
| positive regulation of membrane protein ectodomain proteolysis |
| positive regulation of cellular extravasation |
| positive regulation of lymphocyte apoptotic process |
| positive regulation of bone resorption |
| positive regulation of bone remodeling |
| regulation of membrane protein ectodomain proteolysis |
| positive regulation of protein processing |
| regulation of T cell differentiation in thymus |
| positive regulation of protein maturation |
| positive regulation of leukocyte apoptotic process |
| regulation of cellular extravasation |
| positive regulation of neutrophil migration |
| positive regulation of acute inflammatory response |
| podosome |
| positive regulation of T cell migration |
| positive regulation of tissue remodeling |
| regulation of T cell apoptotic process |
| regulation of neutrophil migration |
| positive regulation of lymphocyte migration |
| regulation of bone resorption |
| regulation of T cell migration |
| regulation of acute inflammatory response |
| lymphocyte chemotaxis |
| regulation of bone remodeling |
| regulation of lymphocyte apoptotic process |
| protein self-association |
| cell adhesion molecule binding |
| ficolin-1-rich granule membrane |
| regulation of lymphocyte migration |
| metallopeptidase activity |
| extracellular matrix disassembly |
| regulation of protein processing |
| lymphocyte migration |
| regulation of protein maturation |
| tertiary granule membrane |
| regulation of tissue remodeling |
| regulation of leukocyte apoptotic process |
| positive regulation of T cell differentiation |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| specific granule membrane |
| positive regulation of lymphocyte differentiation |
| metalloendopeptidase activity |
| positive regulation of leukocyte migration |
| regulation of T cell differentiation |
| positive regulation of inflammatory response |
| negative regulation of neuron apoptotic process |
| leukocyte chemotaxis |
| positive regulation of leukocyte differentiation |
| regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of NF-kappaB transcription factor activity |
| serine-type endopeptidase activity |
| positive regulation of protein kinase B signaling |
| regulation of lymphocyte differentiation |
| cellular response to hypoxia |
| positive regulation of hemopoiesis |
| regulation of leukocyte migration |
| cellular response to decreased oxygen levels |
| positive regulation of T cell activation |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| cell chemotaxis |
| cellular response to oxygen levels |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of protein catabolic process |
| regulation of protein kinase B signaling |
| positive regulation of cell-cell adhesion |
| positive regulation of MAP kinase activity |
| positive regulation of DNA-binding transcription factor activity |
| positive regulation of protein secretion |
| regulation of leukocyte differentiation |
| positive regulation of peptide secretion |
| regulation of leukocyte cell-cell adhesion |
| regulation of neuron death |
| angiogenesis |
| regulation of T cell activation |
| regulation of inflammatory response |
| positive regulation of protein serine/threonine kinase activity |
| extracellular matrix organization |
| positive regulation of innate immune response |
| regulation of MAP kinase activity |
| response to hypoxia |
| response to decreased oxygen levels |
| positive regulation of proteolysis |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| positive regulation of cellular catabolic process |
| leukocyte migration |
| response to oxygen levels |
| regulation of protein catabolic process |
| extracellular structure organization |
| regulation of cell-cell adhesion |
| cellular component disassembly |
| positive regulation of secretion by cell |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| blood vessel morphogenesis |
| positive regulation of cell activation |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| positive regulation of catabolic process |
| positive regulation of secretion |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| positive regulation of defense response |
| blood vessel development |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| regulation of peptide secretion |
| neutrophil mediated immunity |
| inflammatory response |
| positive regulation of cell migration |
| neutrophil activation |
| granulocyte activation |
| cell-cell adhesion |
| positive regulation of multi-organism process |
| vasculature development |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| myeloid leukocyte mediated immunity |
| cardiovascular system development |
| positive regulation of cell motility |
| myeloid cell activation involved in immune response |
| regulation of response to biotic stimulus |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| tube morphogenesis |
| positive regulation of transferase activity |
| regulation of cell adhesion |
| regulation of cytokine production |
| positive regulation of cell death |
| regulated exocytosis |
| regulation of protein transport |
| calcium ion binding |
| cell morphogenesis |
| regulation of proteolysis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| exocytosis |
| regulation of protein kinase activity |
| regulation of secretion |
| cellular component morphogenesis |
| regulation of cellular catabolic process |
| zinc ion binding |
| tube development |
| regulation of cell migration |
| positive regulation of immune response |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| cell migration |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| negative regulation of cell death |
| regulation of catabolic process |
| regulation of cellular component movement |
| secretion by cell |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| export from cell |
| positive regulation of phosphorylation |
| cell activation |
| cell motility |
| localization of cell |
| immune effector process |
| regulation of response to external stimulus |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| response to abiotic stimulus |
| positive regulation of protein modification process |
| proteolysis |
| locomotion |
| defense response |
| positive regulation of developmental process |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Salinomycin 3.5μM R08 exp521 | -1.81 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5399
- Expression level (log2 read counts): 0.44
Expression Distribution
ADAM8 Expression in NALM6 Cells: 0.44
