ADAMTS13 [The Human Chemical-Genetic Interaction Map Project]

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======= ADAMTS13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAMTS13
  * **<color #00a2e8>Official Name</color>**: ADAM metallopeptidase with thrombospondin type 1 motif 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11093|11093]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q76LX8|Q76LX8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAMTS13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAMTS13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604134|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. {ECO:0000269|PubMed:19880749}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Reprolysin|
|TSP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to potassium ion|
|cellular response to interleukin-4|
|peptide catabolic process|
|response to interleukin-4|
|response to amine|
|metallopeptidase activity|
|integrin-mediated signaling pathway|
|metalloendopeptidase activity|
|cell-matrix adhesion|
|integrin binding|
|platelet activation|
|protein processing|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|cell-substrate adhesion|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|cellular response to biotic stimulus|
|protein maturation|
|extracellular matrix|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|blood coagulation|
|coagulation|
|hemostasis|
|endoplasmic reticulum lumen|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|response to metal ion|
|glycoprotein metabolic process|
|wound healing|
|regulation of body fluid levels|
|response to toxic substance|
|cellular response to lipid|
|peptide metabolic process|
|response to inorganic substance|
|response to wounding|
|cell surface|
|response to bacterium|
|calcium ion binding|
|innate immune response|
|cellular amide metabolic process|
|zinc ion binding|
|response to lipid|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|cell activation|
|response to nitrogen compound|
|response to cytokine|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to oxygen-containing compound|
|extracellular space|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.7|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5747
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAMTS13 Expression in NALM6 Cells: -0.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>