ADAMTS13

Entrez Summary: This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
UniProt Summary: Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. {ECO:0000269|PubMed:19880749}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rifampicin 30μM R08 exp430	1.7
Staurosporine 0.02μM R08 exp524	1.71

Reprolysin
TSP 1

response to potassium ion
cellular response to interleukin-4
peptide catabolic process
response to interleukin-4
response to amine
metallopeptidase activity
integrin-mediated signaling pathway
metalloendopeptidase activity
cell-matrix adhesion
integrin binding
platelet activation
protein processing
cellular response to interferon-gamma
response to interferon-gamma
cell-substrate adhesion
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cellular response to biotic stimulus
protein maturation
extracellular matrix
cellular response to tumor necrosis factor
response to tumor necrosis factor
blood coagulation
coagulation
hemostasis
endoplasmic reticulum lumen
response to lipopolysaccharide
response to molecule of bacterial origin
response to metal ion
glycoprotein metabolic process
wound healing
regulation of body fluid levels
response to toxic substance
cellular response to lipid
peptide metabolic process
response to inorganic substance
response to wounding
cell surface
response to bacterium
calcium ion binding