ADAMTS3

Entrez Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016].
UniProt Summary: Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vascular endothelial growth factor production
positive regulation of vascular endothelial growth factor signaling pathway
collagen biosynthetic process
regulation of vascular endothelial growth factor signaling pathway
regulation of cellular response to vascular endothelial growth factor stimulus
collagen catabolic process
collagen fibril organization
collagen metabolic process
endopeptidase activity
metalloendopeptidase activity
cytokine production
protein processing
heparin binding
protein maturation
extracellular matrix
regulation of cellular response to growth factor stimulus
extracellular matrix organization
collagen-containing extracellular matrix
in utero embryonic development
extracellular structure organization
supramolecular fiber organization
chordate embryonic development
embryo development ending in birth or egg hatching
zinc ion binding
embryo development
proteolysis
extracellular space
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
protein-containing complex subunit organization
extracellular region
gene expression