ADAMTS7

• Official Symbol: ADAMTS7
• Official Name: ADAM metallopeptidase with thrombospondin type 1 motif 7
• Aliases and Previous Symbols: N/A
• Entrez ID: 11173
• UniProt: Q9UKP4
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016].
• UniProt Summary: Metalloprotease that may play a role in the degradation of COMP. {ECO:0000269|PubMed:16585064}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 3067
• Expression level (log2 read counts): 3.71

Expression Distribution

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ADAMTS7 Expression in NALM6 Cells: 3.71