ADAMTS8
Gene Information
- Official Symbol: ADAMTS8
- Official Name: ADAM metallopeptidase with thrombospondin type 1 motif 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 11095
- UniProt: Q9UP79
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016].
- UniProt Summary: Has anti-angiogenic properties.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8972
- Expression level (log2 read counts): 0.55
ADAMTS8 Expression in NALM6 Cells: 0.55
