AGL

Entrez Summary: This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
AICAR 240μM R03 exp116	1.76
NFN1 1μM R03 exp100	1.89

amylo-alpha-1,6-glucosidase activity
isoamylase complex
beta-maltose 4-alpha-glucanotransferase activity
4-alpha-glucanotransferase activity
glycogen debranching enzyme activity
glycogen catabolic process
polysaccharide binding
glucan catabolic process
glycogen biosynthetic process
glucan biosynthetic process
inclusion body
cellular polysaccharide catabolic process
polysaccharide catabolic process
polyubiquitin modification-dependent protein binding
cellular carbohydrate catabolic process
cellular polysaccharide biosynthetic process
sarcoplasmic reticulum
polysaccharide biosynthetic process
glycogen metabolic process
cellular glucan metabolic process
glucan metabolic process
cellular carbohydrate biosynthetic process
energy reserve metabolic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
secretory granule lumen
carbohydrate catabolic process
ficolin-1-rich granule lumen
carbohydrate biosynthetic process
response to glucocorticoid
response to corticosteroid
cellular carbohydrate metabolic process
response to nutrient
energy derivation by oxidation of organic compounds
response to steroid hormone
generation of precursor metabolites and energy
carbohydrate metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity