AGTRAP

Entrez Summary: N/A
UniProt Summary: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. {ECO:0000269|PubMed:12960423}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

angiotensin type II receptor activity
angiotensin-activated signaling pathway
cellular response to angiotensin
response to angiotensin
cell cortex
cytoplasmic vesicle membrane
regulation of blood pressure
cellular response to peptide hormone stimulus
cellular response to peptide
response to hypoxia
response to decreased oxygen levels
response to oxygen levels
blood circulation
response to peptide hormone
circulatory system process
response to peptide
cellular response to organonitrogen compound
cellular response to hormone stimulus
Golgi membrane
cellular response to nitrogen compound
intracellular membrane-bounded organelle
response to hormone
endoplasmic reticulum membrane
response to organonitrogen compound
cellular response to oxygen-containing compound
response to nitrogen compound
response to abiotic stimulus
cellular response to endogenous stimulus
G protein-coupled receptor signaling pathway
response to endogenous stimulus
response to oxygen-containing compound
system process