AGXT2

Gene Information

Official Symbol: AGXT2
Official Name: alanine–glyoxylate aminotransferase 2
Aliases and Previous Symbols: N/A
Entrez ID: 64902
UniProt: Q9BYV1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. {ECO:0000269|PubMed:20018850, ECO:0000269|PubMed:23023372, ECO:0000269|PubMed:24586340}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16504
Expression level (log2 read counts): -4.01

Expression Distribution

(R)-3-amino-2-methylpropionate-pyruvate transaminase activity
L-alanine catabolic process, by transamination
alanine-glyoxylate transaminase activity
glycine biosynthetic process, by transamination of glyoxylate
glyoxylate catabolic process
glycine biosynthetic process
L-alanine metabolic process
L-alanine catabolic process
alanine metabolic process
pyruvate family amino acid metabolic process
alanine catabolic process
pyruvate family amino acid catabolic process
glyoxylate metabolic process
aldehyde catabolic process
serine family amino acid biosynthetic process
glycine metabolic process
positive regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide metabolic process
serine family amino acid metabolic process
neurotransmitter biosynthetic process
positive regulation of reactive oxygen species biosynthetic process
cellular aldehyde metabolic process
pyridoxal phosphate binding
regulation of nitric oxide biosynthetic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
regulation of reactive oxygen species biosynthetic process
neurotransmitter metabolic process
positive regulation of reactive oxygen species metabolic process
alpha-amino acid catabolic process
monocarboxylic acid catabolic process
cellular amino acid catabolic process
regulation of reactive oxygen species metabolic process
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
regulation of neurotransmitter levels