AGXT [The Human Chemical-Genetic Interaction Map Project]

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======= AGXT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGXT
  * **<color #00a2e8>Official Name</color>**: alanine--glyoxylate and serine--pyruvate aminotransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=189|189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21549|P21549]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGXT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGXT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604285|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aminotran 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|serine-pyruvate transaminase activity|
|alanine-glyoxylate transaminase activity|
|oxalic acid secretion|
|glycine biosynthetic process, by transamination of glyoxylate|
|glyoxylate catabolic process|
|L-alanine metabolic process|
|glycine biosynthetic process|
|L-cysteine metabolic process|
|cysteine catabolic process|
|L-alanine catabolic process|
|L-cysteine catabolic process|
|alanine metabolic process|
|alanine catabolic process|
|pyruvate family amino acid metabolic process|
|pyruvate family amino acid catabolic process|
|transaminase activity|
|pyruvate biosynthetic process|
|glyoxylate metabolic process|
|cysteine metabolic process|
|oxalate transport|
|aldehyde catabolic process|
|sulfur amino acid catabolic process|
|serine family amino acid catabolic process|
|serine family amino acid biosynthetic process|
|amino acid binding|
|glycine metabolic process|
|sulfur amino acid metabolic process|
|serine family amino acid metabolic process|
|neurotransmitter biosynthetic process|
|peroxisomal matrix|
|cellular aldehyde metabolic process|
|pyridoxal phosphate binding|
|sulfur compound catabolic process|
|protein self-association|
|alpha-amino acid biosynthetic process|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|pyruvate metabolic process|
|peroxisome organization|
|dicarboxylic acid transport|
|acid secretion|
|cellular amino acid biosynthetic process|
|neurotransmitter metabolic process|
|response to cAMP|
|alpha-amino acid catabolic process|
|peroxisome|
|monocarboxylic acid catabolic process|
|Notch signaling pathway|
|cellular amino acid catabolic process|
|response to organophosphorus|
|response to glucocorticoid|
|response to purine-containing compound|
|response to corticosteroid|
|monocarboxylic acid biosynthetic process|
|alpha-amino acid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|organic acid transport|
|carboxylic acid transport|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|response to steroid hormone|
|regulation of neurotransmitter levels|
|protein targeting|
|sulfur compound metabolic process|
|mitochondrial matrix|
|establishment of protein localization to organelle|
|small molecule catabolic process|
|organic anion transport|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|anion transport|
|small molecule biosynthetic process|
|intracellular membrane-bounded organelle|
|protein localization to organelle|
|response to lipid|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|intracellular protein transport|
|response to organonitrogen compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to nitrogen compound|
|secretion|
|ion transport|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3025
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGXT Expression in NALM6 Cells: 1.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>