AGXT

Entrez Summary: This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

serine-pyruvate transaminase activity
alanine-glyoxylate transaminase activity
oxalic acid secretion
glycine biosynthetic process, by transamination of glyoxylate
glyoxylate catabolic process
L-alanine metabolic process
glycine biosynthetic process
L-cysteine metabolic process
cysteine catabolic process
L-alanine catabolic process
L-cysteine catabolic process
alanine metabolic process
alanine catabolic process
pyruvate family amino acid metabolic process
pyruvate family amino acid catabolic process
transaminase activity
pyruvate biosynthetic process
glyoxylate metabolic process
cysteine metabolic process
oxalate transport
aldehyde catabolic process
sulfur amino acid catabolic process
serine family amino acid catabolic process
serine family amino acid biosynthetic process
amino acid binding
glycine metabolic process
sulfur amino acid metabolic process
serine family amino acid metabolic process
neurotransmitter biosynthetic process
peroxisomal matrix
cellular aldehyde metabolic process
pyridoxal phosphate binding
sulfur compound catabolic process
protein self-association
alpha-amino acid biosynthetic process
protein localization to peroxisome
protein targeting to peroxisome
establishment of protein localization to peroxisome
peroxisomal transport
pyruvate metabolic process