AIM2

Gene Information

Official Symbol: AIM2
Official Name: absent in melanoma 2
Aliases and Previous Symbols: N/A
Entrez ID: 9447
UniProt: O14862
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:16432157, ECO:0000269|PubMed:17726700, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679, ECO:0000269|PubMed:20566831}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13599
Expression level (log2 read counts): -2.6

Expression Distribution

PAAD DAPIN
HIN

AIM2 inflammasome complex
interleukin-1 beta secretion
pyroptosis
interleukin-1 secretion
interleukin-1 beta production
interleukin-1 production
cellular response to interferon-beta
positive regulation of protein oligomerization
positive regulation of defense response to virus by host
response to interferon-beta
positive regulation of interleukin-1 beta secretion
regulation of defense response to virus by host
positive regulation of interleukin-1 secretion
regulation of protein oligomerization
regulation of interleukin-1 beta secretion
cytokine secretion
positive regulation of interleukin-1 beta production
regulation of interleukin-1 secretion
positive regulation of interleukin-1 production
regulation of defense response to virus
regulation of interleukin-1 beta production
negative regulation of NF-kappaB transcription factor activity
regulation of interleukin-1 production
double-stranded DNA binding
tumor necrosis factor-mediated signaling pathway
positive regulation of cytokine secretion
cytokine production
positive regulation of cysteine-type endopeptidase activity
positive regulation of NF-kappaB transcription factor activity
protein secretion
establishment of protein localization to extracellular region
negative regulation of DNA-binding transcription factor activity
protein localization to extracellular region
positive regulation of endopeptidase activity
peptide secretion
positive regulation of peptidase activity
regulation of cytokine secretion
cellular response to tumor necrosis factor
regulation of cysteine-type endopeptidase activity
positive regulation of protein complex assembly