AIMP2

Official Symbol: AIMP2
Official Name: aminoacyl tRNA synthetase complex interacting multifunctional protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 7965
UniProt: Q13155
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016].
UniProt Summary: Required for assembly and stability of the aminoacyl- tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:19131329}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
DABN racemic mixture R03 exp93	1.71
Vinblastine 0.015μM R05 exp208	2.01

positive regulation of aminoacyl-tRNA ligase activity
regulation of aminoacyl-tRNA ligase activity
type II pneumocyte differentiation
positive regulation of ligase activity
lung secretory cell differentiation
regulation of ligase activity
aminoacyl-tRNA synthetase multienzyme complex
lung epithelial cell differentiation
lung cell differentiation
lung epithelium development
tRNA aminoacylation for protein translation
molecular adaptor activity
tRNA aminoacylation
amino acid activation
positive regulation of neuron death
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
lung development
respiratory tube development
tRNA metabolic process
respiratory system development
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
cellular amino acid metabolic process
regulation of neuron death
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
negative regulation of cell population proliferation
epithelial cell differentiation
positive regulation of cell death
cellular amide metabolic process
tube development
carboxylic acid metabolic process
apoptotic process
oxoacid metabolic process
organic acid metabolic process
programmed cell death