AK5

Gene Information

Official Symbol: AK5
Official Name: adenylate kinase 5
Aliases and Previous Symbols: N/A
Entrez ID: 26289
UniProt: Q9Y6K8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:19647735, ECO:0000269|PubMed:23416111}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7246
Expression level (log2 read counts): 1.94

Expression Distribution

Dpy-30
ADK

dADP biosynthetic process
purine deoxyribonucleoside diphosphate biosynthetic process
dADP metabolic process
purine deoxyribonucleotide biosynthetic process
purine deoxyribonucleoside diphosphate metabolic process
deoxyribonucleoside diphosphate biosynthetic process
ADP biosynthetic process
deoxyribonucleoside diphosphate metabolic process
purine nucleoside diphosphate biosynthetic process
purine ribonucleoside diphosphate biosynthetic process
ribonucleoside diphosphate biosynthetic process
adenylate kinase activity
nucleoside diphosphate biosynthetic process
purine deoxyribonucleotide metabolic process
2-deoxyribonucleotide biosynthetic process
deoxyribose phosphate biosynthetic process
nucleoside monophosphate phosphorylation
deoxyribonucleotide biosynthetic process
nucleoside diphosphate kinase activity
pyrimidine ribonucleotide biosynthetic process
pyrimidine ribonucleotide metabolic process
nucleobase-containing small molecule interconversion
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
deoxyribonucleotide metabolic process
pyrimidine nucleotide biosynthetic process
ADP metabolic process
pyrimidine-containing compound biosynthetic process
nucleoside diphosphate phosphorylation
pyrimidine nucleotide metabolic process
nucleotide phosphorylation
purine ribonucleoside diphosphate metabolic process
purine nucleoside diphosphate metabolic process
nucleoside triphosphate biosynthetic process
ribonucleoside diphosphate metabolic process
nucleoside monophosphate metabolic process
nucleoside diphosphate metabolic process
nucleoside triphosphate metabolic process
pyrimidine-containing compound metabolic process
purine ribonucleotide biosynthetic process