AKAP5

Entrez Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008].
UniProt Summary: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

beta-2 adrenergic receptor binding
glutamate receptor binding
protein phosphatase 2B binding
positive regulation of adenylate cyclase activity
adenylate cyclase binding
GABA receptor binding
negative regulation of adenylate cyclase activity
regulation of protein kinase A signaling
negative regulation of cyclase activity
protein kinase A regulatory subunit binding
positive regulation of cyclase activity
negative regulation of lyase activity
positive regulation of lyase activity
protein kinase A binding
regulation of adenylate cyclase activity
dendrite membrane
excitatory synapse
regulation of cyclase activity
regulation of lyase activity
cytoplasmic side of plasma membrane
positive regulation of protein localization to plasma membrane
scaffold protein binding
positive regulation of protein localization to cell periphery
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
regulation of protein localization to plasma membrane
regulation of protein localization to cell periphery
positive regulation of protein localization to membrane
SH3 domain binding
dendritic spine
regulation of protein localization to membrane
calmodulin binding
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
membrane raft
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
postsynaptic density
positive regulation of cellular protein localization
protein targeting
chemical synaptic transmission
anterograde trans-synaptic signaling
trans-synaptic signaling