AKAP6 [The Human Chemical-Genetic Interaction Map Project]

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======= AKAP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKAP6
  * **<color #00a2e8>Official Name</color>**: A-kinase anchoring protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9472|9472]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13023|Q13023]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKAP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKAP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604691|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of delayed rectifier potassium channel activity|
|positive regulation of ryanodine-sensitive calcium-release channel activity|
|positive regulation of cell growth involved in cardiac muscle cell development|
|junctional sarcoplasmic reticulum membrane|
|adenylate cyclase binding|
|protein membrane anchor|
|positive regulation of voltage-gated potassium channel activity|
|positive regulation of calcineurin-mediated signaling|
|positive regulation of calcineurin-NFAT signaling cascade|
|regulation of cell growth involved in cardiac muscle cell development|
|regulation of delayed rectifier potassium channel activity|
|positive regulation of cardiac muscle cell differentiation|
|regulation of protein kinase A signaling|
|protein kinase A regulatory subunit binding|
|positive regulation of potassium ion transmembrane transporter activity|
|calcium channel complex|
|protein kinase A binding|
|regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|positive regulation of cardiocyte differentiation|
|positive regulation of cardiac muscle hypertrophy|
|positive regulation of muscle hypertrophy|
|positive regulation of cardiac muscle tissue growth|
|regulation of membrane repolarization|
|regulation of calcineurin-mediated signaling|
|regulation of calcineurin-NFAT signaling cascade|
|regulation of cardiac muscle cell differentiation|
|positive regulation of heart growth|
|positive regulation of potassium ion transmembrane transport|
|positive regulation of calcium ion transmembrane transporter activity|
|positive regulation of release of sequestered calcium ion into cytosol|
|T-tubule|
|positive regulation of calcium-mediated signaling|
|sarcoplasmic reticulum|
|positive regulation of cardiac muscle tissue development|
|intercalated disc|
|positive regulation of potassium ion transport|
|molecular adaptor activity|
|positive regulation of organ growth|
|regulation of cardiocyte differentiation|
|cellular response to cAMP|
|positive regulation of calcium ion transport into cytosol|
|regulation of potassium ion transmembrane transporter activity|
|regulation of cardiac muscle hypertrophy|
|regulation of cardiac muscle tissue growth|
|positive regulation of striated muscle cell differentiation|
|regulation of muscle hypertrophy|
|regulation of heart growth|
|positive regulation of striated muscle tissue development|
|positive regulation of cation channel activity|
|positive regulation of muscle organ development|
|positive regulation of muscle tissue development|
|positive regulation of calcium ion transmembrane transport|
|caveola|
|regulation of release of sequestered calcium ion into cytosol|
|regulation of cardiac muscle tissue development|
|regulation of potassium ion transmembrane transport|
|regulation of muscle adaptation|
|positive regulation of muscle cell differentiation|
|regulation of calcium ion transmembrane transporter activity|
|regulation of organ growth|
|action potential|
|regulation of potassium ion transport|
|regulation of calcium-mediated signaling|
|response to cAMP|
|regulation of calcium ion transport into cytosol|
|regulation of striated muscle cell differentiation|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|ion channel binding|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|response to organophosphorus|
|regulation of muscle organ development|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|cAMP-mediated signaling|
|response to purine-containing compound|
|regulation of muscle cell differentiation|
|positive regulation of ion transmembrane transport|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|cyclic-nucleotide-mediated signaling|
|regulation of cation channel activity|
|nuclear envelope|
|positive regulation of transmembrane transport|
|regulation of muscle system process|
|nuclear membrane|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|positive regulation of growth|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|regulation of developmental growth|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|protein targeting|
|regulation of metal ion transport|
|regulation of cell growth|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|regulation of system process|
|cellular response to organonitrogen compound|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|regulation of growth|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of cell development|
|positive regulation of cell differentiation|
|positive regulation of transport|
|intracellular protein transport|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.79|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.86|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4616
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKAP6 Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>