AKAP6
Gene Information
- Official Symbol: AKAP6
- Official Name: A-kinase anchoring protein 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 9472
- UniProt: Q13023
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of delayed rectifier potassium channel activity |
| positive regulation of ryanodine-sensitive calcium-release channel activity |
| positive regulation of cell growth involved in cardiac muscle cell development |
| junctional sarcoplasmic reticulum membrane |
| adenylate cyclase binding |
| protein membrane anchor |
| positive regulation of voltage-gated potassium channel activity |
| positive regulation of calcineurin-mediated signaling |
| positive regulation of calcineurin-NFAT signaling cascade |
| regulation of cell growth involved in cardiac muscle cell development |
| regulation of delayed rectifier potassium channel activity |
| positive regulation of cardiac muscle cell differentiation |
| regulation of protein kinase A signaling |
| protein kinase A regulatory subunit binding |
| positive regulation of potassium ion transmembrane transporter activity |
| calcium channel complex |
| protein kinase A binding |
| regulation of ryanodine-sensitive calcium-release channel activity |
| regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| positive regulation of cardiocyte differentiation |
| positive regulation of cardiac muscle hypertrophy |
| positive regulation of muscle hypertrophy |
| positive regulation of cardiac muscle tissue growth |
| regulation of membrane repolarization |
| regulation of calcineurin-mediated signaling |
| regulation of calcineurin-NFAT signaling cascade |
| regulation of cardiac muscle cell differentiation |
| positive regulation of heart growth |
| positive regulation of potassium ion transmembrane transport |
| positive regulation of calcium ion transmembrane transporter activity |
| positive regulation of release of sequestered calcium ion into cytosol |
| T-tubule |
| positive regulation of calcium-mediated signaling |
| sarcoplasmic reticulum |
| positive regulation of cardiac muscle tissue development |
| intercalated disc |
| positive regulation of potassium ion transport |
| molecular adaptor activity |
| positive regulation of organ growth |
| regulation of cardiocyte differentiation |
| cellular response to cAMP |
| positive regulation of calcium ion transport into cytosol |
| regulation of potassium ion transmembrane transporter activity |
| regulation of cardiac muscle hypertrophy |
| regulation of cardiac muscle tissue growth |
| positive regulation of striated muscle cell differentiation |
| regulation of muscle hypertrophy |
| regulation of heart growth |
| positive regulation of striated muscle tissue development |
| positive regulation of cation channel activity |
| positive regulation of muscle organ development |
| positive regulation of muscle tissue development |
| positive regulation of calcium ion transmembrane transport |
| caveola |
| regulation of release of sequestered calcium ion into cytosol |
| regulation of cardiac muscle tissue development |
| regulation of potassium ion transmembrane transport |
| regulation of muscle adaptation |
| positive regulation of muscle cell differentiation |
| regulation of calcium ion transmembrane transporter activity |
| regulation of organ growth |
| action potential |
| regulation of potassium ion transport |
| regulation of calcium-mediated signaling |
| response to cAMP |
| regulation of calcium ion transport into cytosol |
| regulation of striated muscle cell differentiation |
| positive regulation of ion transmembrane transporter activity |
| positive regulation of transporter activity |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| ion channel binding |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| response to organophosphorus |
| regulation of muscle organ development |
| positive regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transport |
| cAMP-mediated signaling |
| response to purine-containing compound |
| regulation of muscle cell differentiation |
| positive regulation of ion transmembrane transport |
| positive regulation of cell growth |
| positive regulation of developmental growth |
| cyclic-nucleotide-mediated signaling |
| regulation of cation channel activity |
| nuclear envelope |
| positive regulation of transmembrane transport |
| regulation of muscle system process |
| nuclear membrane |
| regulation of calcium ion transport |
| regulation of ion transmembrane transporter activity |
| positive regulation of growth |
| regulation of transmembrane transporter activity |
| positive regulation of ion transport |
| regulation of transporter activity |
| positive regulation of cytosolic calcium ion concentration |
| regulation of cytosolic calcium ion concentration |
| regulation of developmental growth |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| protein targeting |
| regulation of metal ion transport |
| regulation of cell growth |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| divalent inorganic cation homeostasis |
| positive regulation of cell development |
| cellular response to organic cyclic compound |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| regulation of system process |
| cellular response to organonitrogen compound |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cellular response to nitrogen compound |
| regulation of growth |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| cellular homeostasis |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of cell development |
| positive regulation of cell differentiation |
| positive regulation of transport |
| intracellular protein transport |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| response to cytokine |
| chemical homeostasis |
| cellular response to endogenous stimulus |
| positive regulation of developmental process |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| peptide transport |
| response to oxygen-containing compound |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| homeostatic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4616
- Expression level (log2 read counts): 3.4
Expression Distribution
AKAP6 Expression in NALM6 Cells: 3.4
