AKR1A1 [The Human Chemical-Genetic Interaction Map Project]

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======= AKR1A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKR1A1
  * **<color #00a2e8>Official Name</color>**: aldo-keto reductase family 1 member A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10327|10327]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14550|P14550]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKR1A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKR1A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). {ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097, ECO:0000269|PubMed:18276838}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldo ket red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|D-glucuronate metabolic process|
|L-glucuronate reductase activity|
|D-glucuronate catabolic process|
|glucuronolactone reductase activity|
|L-ascorbic acid biosynthetic process|
|allyl-alcohol dehydrogenase activity|
|glucuronate catabolic process|
|xylulose 5-phosphate metabolic process|
|xylulose 5-phosphate biosynthetic process|
|glucuronate catabolic process to xylulose 5-phosphate|
|cellular detoxification of aldehyde|
|daunorubicin metabolic process|
|polyketide metabolic process|
|doxorubicin metabolic process|
|water-soluble vitamin biosynthetic process|
|cellular response to aldehyde|
|aminoglycoside antibiotic metabolic process|
|aldo-keto reductase (NADP) activity|
|L-ascorbic acid metabolic process|
|aldehyde catabolic process|
|alcohol dehydrogenase (NADP+) activity|
|alditol:NADP+ 1-oxidoreductase activity|
|tertiary alcohol metabolic process|
|vitamin biosynthetic process|
|glycoside metabolic process|
|retinol dehydrogenase activity|
|glutathione derivative biosynthetic process|
|glutathione derivative metabolic process|
|glucuronate metabolic process|
|uronic acid metabolic process|
|quinone metabolic process|
|monosaccharide biosynthetic process|
|cellular aldehyde metabolic process|
|secondary metabolic process|
|monosaccharide catabolic process|
|cellular ketone metabolic process|
|electron transfer activity|
|primary alcohol metabolic process|
|water-soluble vitamin metabolic process|
|cellular detoxification|
|antibiotic metabolic process|
|glucose metabolic process|
|monocarboxylic acid catabolic process|
|oxidoreductase activity|
|carbohydrate catabolic process|
|vitamin metabolic process|
|carbohydrate biosynthetic process|
|detoxification|
|glycosyl compound metabolic process|
|coenzyme biosynthetic process|
|hexose metabolic process|
|electron transport chain|
|sulfur compound biosynthetic process|
|ammonium ion metabolic process|
|monosaccharide metabolic process|
|cofactor biosynthetic process|
|cellular response to toxic substance|
|coenzyme metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|synapse|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|alcohol metabolic process|
|apical plasma membrane|
|sulfur compound metabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|drug metabolic process|
|response to toxic substance|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound biosynthetic process|
|response to oxygen-containing compound|
|extracellular space|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.71|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.73|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.78|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2405
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKR1A1 Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>