AKR1A1

Entrez Summary: N/A
UniProt Summary: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). {ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097, ECO:0000269|PubMed:18276838}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

D-glucuronate metabolic process
L-glucuronate reductase activity
D-glucuronate catabolic process
glucuronolactone reductase activity
L-ascorbic acid biosynthetic process
allyl-alcohol dehydrogenase activity
glucuronate catabolic process
xylulose 5-phosphate metabolic process
xylulose 5-phosphate biosynthetic process
glucuronate catabolic process to xylulose 5-phosphate
cellular detoxification of aldehyde
daunorubicin metabolic process
polyketide metabolic process
doxorubicin metabolic process
water-soluble vitamin biosynthetic process
cellular response to aldehyde
aminoglycoside antibiotic metabolic process
aldo-keto reductase (NADP) activity
L-ascorbic acid metabolic process
aldehyde catabolic process
alcohol dehydrogenase (NADP+) activity
alditol:NADP+ 1-oxidoreductase activity
tertiary alcohol metabolic process
vitamin biosynthetic process
glycoside metabolic process
retinol dehydrogenase activity
glutathione derivative biosynthetic process
glutathione derivative metabolic process
glucuronate metabolic process
uronic acid metabolic process
quinone metabolic process
monosaccharide biosynthetic process
cellular aldehyde metabolic process
secondary metabolic process
monosaccharide catabolic process
cellular ketone metabolic process
electron transfer activity
primary alcohol metabolic process
water-soluble vitamin metabolic process
cellular detoxification