AKR1C2

Entrez Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
UniProt Summary: Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. {ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:8573067}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phenanthrene 9,10-monooxygenase activity
response to jasmonic acid
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
cellular response to jasmonic acid stimulus
response to prostaglandin D
cellular response to prostaglandin D stimulus
ketosteroid monooxygenase activity
bile acid binding
carboxylic acid binding
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
doxorubicin metabolic process
polyketide metabolic process
daunorubicin metabolic process
steroid dehydrogenase activity
aminoglycoside antibiotic metabolic process
alcohol dehydrogenase (NADP+) activity
progesterone metabolic process
tertiary alcohol metabolic process
alditol:NADP+ 1-oxidoreductase activity
glycoside metabolic process
cellular response to prostaglandin stimulus
C21-steroid hormone metabolic process
response to prostaglandin
quinone metabolic process
prostanoid metabolic process
prostaglandin metabolic process
secondary metabolic process
cellular response to fatty acid
cellular ketone metabolic process
primary alcohol metabolic process
response to fatty acid
cellular response to alcohol
cellular response to ketone
antibiotic metabolic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
digestion
oxidoreductase activity
cellular hormone metabolic process
glycosyl compound metabolic process