AKR1D1

Entrez Summary: The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. [provided by RefSeq, Jul 2010].
UniProt Summary: Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates. {ECO:0000269|PubMed:11342103}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Trientine 500μM R08 exp534	-1.86
Cryptotanshinone 12μM R05 exp227	-1.74

delta4-3-oxosteroid 5beta-reductase activity
bile acid catabolic process
ketosteroid monooxygenase activity
steroid dehydrogenase activity
aldo-keto reductase (NADP) activity
alcohol dehydrogenase (NADP+) activity
cholesterol catabolic process
sterol catabolic process
alditol:NADP+ 1-oxidoreductase activity
androgen metabolic process
bile acid biosynthetic process
steroid catabolic process
C21-steroid hormone metabolic process
steroid binding
bile acid metabolic process
alcohol catabolic process
organic hydroxy compound catabolic process
digestion
monocarboxylic acid catabolic process
cholesterol metabolic process
oxidoreductase activity
cellular hormone metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
monocarboxylic acid biosynthetic process
organic hydroxy compound biosynthetic process
hormone metabolic process
steroid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
alcohol metabolic process
small molecule catabolic process
organic hydroxy compound metabolic process
organic cyclic compound catabolic process
monocarboxylic acid metabolic process
regulation of hormone levels