AKR7A2

Entrez Summary: N/A
UniProt Summary: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:17591773, ECO:0000269|PubMed:9576847}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phenanthrene-9,10-epoxide hydrolase activity
doxorubicin metabolic process
polyketide metabolic process
daunorubicin metabolic process
aminoglycoside antibiotic metabolic process
tertiary alcohol metabolic process
alditol:NADP+ 1-oxidoreductase activity
glycoside metabolic process
quinone metabolic process
cellular aldehyde metabolic process
secondary metabolic process
cellular ketone metabolic process
electron transfer activity
primary alcohol metabolic process
antibiotic metabolic process
xenobiotic metabolic process
glycosyl compound metabolic process
electron transport chain
cellular response to xenobiotic stimulus
ammonium ion metabolic process
response to xenobiotic stimulus
alcohol metabolic process
generation of precursor metabolites and energy
cofactor metabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
drug metabolic process
oxidation-reduction process
Golgi apparatus
carbohydrate derivative metabolic process
small molecule metabolic process