ALDH6A1

Entrez Summary: This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
UniProt Summary: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Doxycycline 10μM R00 exp18	-2.07
GSK-J4 1μM R07 exp362	-1.72

malonate-semialdehyde dehydrogenase (acetylating) activity
methylmalonate-semialdehyde dehydrogenase (acylating) activity
thymine catabolic process
thymine metabolic process
valine catabolic process
valine metabolic process
pyrimidine nucleobase catabolic process
nucleobase catabolic process
fatty-acyl-CoA binding
pyrimidine nucleobase metabolic process
branched-chain amino acid catabolic process
branched-chain amino acid metabolic process
brown fat cell differentiation
nucleobase metabolic process
pyrimidine-containing compound catabolic process
fat cell differentiation
pyrimidine-containing compound metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
mitochondrial matrix
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
mitochondrion
RNA binding
small molecule metabolic process
organic substance catabolic process
cellular catabolic process