ALOX12

Entrez Summary: N/A
UniProt Summary: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750, ECO:0000269|PubMed:22237009, ECO:0000269|PubMed:23578768, ECO:0000269|PubMed:8250832, ECO:0000269|PubMed:9751607}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Lipoxygenase
PLAT

leukotriene A4 metabolic process
oxylipin metabolic process
lipoxin B4 metabolic process
lipoxin B4 biosynthetic process
lipoxin A4 biosynthetic process
positive regulation of endothelial tube morphogenesis
linoleate 13S-lipoxygenase activity
lipoxin A4 metabolic process
hepoxilin-epoxide hydrolase activity
arachidonate 12-lipoxygenase activity
epoxide metabolic process
hepoxilin metabolic process
hepoxilin biosynthetic process
lipoxin biosynthetic process
regulation of endothelial tube morphogenesis
lipoxin metabolic process
positive regulation of mitochondrial depolarization
negative regulation of platelet aggregation
positive regulation of membrane depolarization
negative regulation of homotypic cell-cell adhesion
lipoxygenase pathway
superoxide anion generation
ether metabolic process
linoleic acid metabolic process
regulation of platelet aggregation
negative regulation of platelet activation
regulation of mitochondrial depolarization
establishment of skin barrier
regulation of homotypic cell-cell adhesion
regulation of water loss via skin
long-chain fatty acid biosynthetic process
leukotriene metabolic process
regulation of platelet activation
positive regulation of morphogenesis of an epithelium
negative regulation of muscle cell apoptotic process
superoxide metabolic process
unsaturated fatty acid biosynthetic process
regulation of membrane depolarization
icosanoid biosynthetic process
negative regulation of blood coagulation