ALOX12B

Entrez Summary: This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq, Sep 2015].
UniProt Summary: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)- hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins. {ECO:0000269|PubMed:21558561, ECO:0000269|PubMed:22441738, ECO:0000269|PubMed:9618483}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
2-Methoxyestradiol 0.55μM R07 exp310	1.74
LB-100 2μM R05 exp210	1.81

PLAT
Lipoxygenase

linoleate 9S-lipoxygenase activity
arachidonate 12-lipoxygenase activity
hepoxilin metabolic process
hepoxilin biosynthetic process
positive regulation of mucus secretion
regulation of mucus secretion
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
lipoxygenase pathway
linoleic acid metabolic process
establishment of skin barrier
regulation of water loss via skin
long-chain fatty acid biosynthetic process
unsaturated fatty acid biosynthetic process
ceramide biosynthetic process
arachidonic acid metabolic process
multicellular organismal water homeostasis
water homeostasis
ceramide metabolic process
protein lipidation
sphingolipid biosynthetic process
lipoprotein biosynthetic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
lipoprotein metabolic process
membrane lipid biosynthetic process
iron ion binding
sphingolipid metabolic process
fatty acid derivative metabolic process
monocarboxylic acid biosynthetic process
membrane lipid metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
multicellular organismal homeostasis
skin development
positive regulation of secretion
regulation of body fluid levels
amide biosynthetic process