AMER1

Gene Information

Official Symbol: AMER1
Official Name: APC membrane recruitment protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 139285
UniProt: Q5JTC6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010].
UniProt Summary: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta- catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12332
Expression level (log2 read counts): 4.58

Expression Distribution

Screen	Score
Taxol 0.004μM R03 exp103	-1.91
BAY-598 4μM R05 exp220	-1.73

beta-catenin destruction complex binding
beta-catenin destruction complex assembly
mesenchymal cell differentiation involved in renal system development
mesenchymal cell differentiation involved in kidney development
kidney mesenchyme development
beta-catenin destruction complex disassembly
adipose tissue development
cell differentiation involved in kidney development
phosphatidylinositol-4,5-bisphosphate binding
beta-catenin binding
canonical Wnt signaling pathway
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
positive regulation of cellular protein catabolic process
positive regulation of canonical Wnt signaling pathway
mesenchymal cell differentiation
negative regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
bone development
regulation of protein ubiquitination
negative regulation of Wnt signaling pathway
positive regulation of protein catabolic process
mesenchyme development
connective tissue development
regulation of protein modification by small protein conjugation or removal
protein-containing complex disassembly
regulation of cellular protein catabolic process
kidney development
regulation of canonical Wnt signaling pathway
nuclear body
renal system development
urogenital system development
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
positive regulation of cellular catabolic process
regulation of protein catabolic process
cellular component disassembly
cell surface receptor signaling pathway involved in cell-cell signaling
positive regulation of catabolic process