AMOTL2

Entrez Summary: N/A
UniProt Summary: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. {ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

establishment of cell polarity involved in ameboidal cell migration
hippo signaling
recycling endosome
establishment of cell polarity
bicellular tight junction
ameboidal-type cell migration
establishment or maintenance of cell polarity
cytoplasmic vesicle
angiogenesis
apical plasma membrane
Wnt signaling pathway
cell-cell signaling by wnt
blood vessel morphogenesis
cell surface receptor signaling pathway involved in cell-cell signaling
blood vessel development
actin cytoskeleton organization
vasculature development
cardiovascular system development
actin filament-based process
tube morphogenesis
tube development
regulation of cell migration
circulatory system development
anatomical structure formation involved in morphogenesis
regulation of cell motility
cell migration
regulation of locomotion
regulation of cellular component movement
identical protein binding
cell motility
localization of cell
cytoskeleton organization
cell-cell signaling
locomotion
movement of cell or subcellular component
intracellular signal transduction