ANKZF1

Gene Information

Official Symbol: ANKZF1
Official Name: ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1
Aliases and Previous Symbols: N/A
Entrez ID: 55139
UniProt: Q9H8Y5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:28302725}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15693
Expression level (log2 read counts): 6.06

Expression Distribution

Ank
Ank 2

Cdc48p-Npl4p-Vms1p AAA ATPase complex
mitochondria-associated ubiquitin-dependent protein catabolic process
nuclear protein quality control by the ubiquitin-proteasome system
cellular response to misfolded protein
response to misfolded protein
protein quality control for misfolded or incompletely synthesized proteins
cellular response to hydrogen peroxide
ubiquitin-dependent ERAD pathway
ERAD pathway
thiol-dependent ubiquitin-specific protease activity
cellular response to antibiotic
response to hydrogen peroxide
cellular response to reactive oxygen species
cellular response to topologically incorrect protein
response to topologically incorrect protein
nucleic acid binding
response to reactive oxygen species
cellular response to toxic substance
cellular response to oxidative stress
response to endoplasmic reticulum stress
response to antibiotic
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
response to oxidative stress
cellular response to drug
response to toxic substance
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
response to inorganic substance
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
cellular macromolecule catabolic process
response to organonitrogen compound
response to drug
macromolecule catabolic process
cellular response to oxygen-containing compound
organonitrogen compound catabolic process
response to nitrogen compound