ANO1

Gene Information

Official Symbol: ANO1
Official Name: anoctamin 1
Aliases and Previous Symbols: N/A
Entrez ID: 55107
UniProt: Q5XXA6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21984732, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12211
Expression level (log2 read counts): -4.01

Expression Distribution

Screen	Score
Nifurtimox 1μM R03 exp141	-1.96
Olaparib 4μM R08 exp512	-1.95

iodide transmembrane transporter activity
iodide transport
voltage-gated chloride channel activity
calcium activated cation channel activity
detection of temperature stimulus involved in sensory perception
detection of temperature stimulus involved in sensory perception of pain
intracellular calcium activated chloride channel activity
detection of temperature stimulus
sensory perception of temperature stimulus
positive regulation of insulin secretion involved in cellular response to glucose stimulus
chloride channel complex
chloride channel activity
regulation of insulin secretion involved in cellular response to glucose stimulus
cellular response to heat
positive regulation of insulin secretion
sensory perception of pain
chloride transmembrane transport
phospholipase C-activating G protein-coupled receptor signaling pathway
positive regulation of peptide hormone secretion
chloride transport
inorganic anion transmembrane transport
response to heat
detection of external stimulus
detection of abiotic stimulus
positive regulation of hormone secretion
inorganic anion transport
response to temperature stimulus
regulation of insulin secretion
regulation of peptide hormone secretion
regulation of hormone secretion
positive regulation of protein secretion
anion transmembrane transport
positive regulation of peptide secretion
apical plasma membrane
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion