AOAH [The Human Chemical-Genetic Interaction Map Project]

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======= AOAH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AOAH
  * **<color #00a2e8>Official Name</color>**: acyloxyacyl hydrolase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=313|313]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28039|P28039]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AOAH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AOAH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102593|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity). {ECO:0000250|UniProtKB:O35298, ECO:0000269|PubMed:1883828, ECO:0000269|PubMed:8089145}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipase GDSL|
|SapB 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipopolysaccharide metabolic process|
|lipopolysaccharide catabolic process|
|acyloxyacyl hydrolase activity|
|cellular polysaccharide catabolic process|
|polysaccharide catabolic process|
|cellular carbohydrate catabolic process|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|liposaccharide metabolic process|
|carbohydrate catabolic process|
|cellular carbohydrate metabolic process|
|carbohydrate derivative catabolic process|
|cellular lipid catabolic process|
|cytoplasmic vesicle|
|lipid catabolic process|
|fatty acid metabolic process|
|carbohydrate metabolic process|
|monocarboxylic acid metabolic process|
|calcium ion binding|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|lipid metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.01|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.8|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.77|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.31|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.53|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.66|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4826
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AOAH Expression in NALM6 Cells: 1.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>