AOAH

Entrez Summary: N/A
UniProt Summary: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity). {ECO:0000250|UniProtKB:O35298, ECO:0000269|PubMed:1883828, ECO:0000269|PubMed:8089145}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.01
JQ1 0.01μM R03 exp130	-1.8
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.77
R-DABN 8μM R03 exp111	2.31
Rotenone 2μM R00 exp33	2.53
Vinblastine 0.015μM R05 exp208	2.66
SB743921 0.001μM R05 exp244	3.15

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Lipase GDSL
SapB 2

lipopolysaccharide metabolic process
lipopolysaccharide catabolic process
acyloxyacyl hydrolase activity
cellular polysaccharide catabolic process
polysaccharide catabolic process
cellular carbohydrate catabolic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
liposaccharide metabolic process
carbohydrate catabolic process
cellular carbohydrate metabolic process
carbohydrate derivative catabolic process
cellular lipid catabolic process
cytoplasmic vesicle
lipid catabolic process
fatty acid metabolic process
carbohydrate metabolic process
monocarboxylic acid metabolic process
calcium ion binding
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
macromolecule catabolic process
lipid metabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
extracellular region