AOC2 [The Human Chemical-Genetic Interaction Map Project]

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======= AOC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AOC2
  * **<color #00a2e8>Official Name</color>**: amine oxidase copper containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=314|314]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75106|O75106]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AOC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AOC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602268|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cu amine oxidN3|
|Cu amine oxid|
|Cu amine oxidN2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tryptamine:oxygen oxidoreductase (deaminating) activity|
|aliphatic-amine oxidase activity|
|phenethylamine:oxygen oxidoreductase (deaminating) activity|
|aminoacetone:oxygen oxidoreductase(deaminating) activity|
|primary amine oxidase activity|
|quinone binding|
|catechol-containing compound metabolic process|
|catecholamine metabolic process|
|copper ion binding|
|amine metabolic process|
|electron transfer activity|
|phenol-containing compound metabolic process|
|xenobiotic metabolic process|
|electron transport chain|
|cellular response to xenobiotic stimulus|
|visual perception|
|sensory perception of light stimulus|
|response to xenobiotic stimulus|
|generation of precursor metabolites and energy|
|organic hydroxy compound metabolic process|
|oxidation-reduction process|
|sensory perception|
|nervous system process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.81|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.74|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.82|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6877
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AOC2 Expression in NALM6 Cells: 2.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>