AOC2

Entrez Summary: N/A
UniProt Summary: Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.81
CI-1040 9.5μM R08 exp472	-1.74
Glyphosate 1000μM R06 exp283	1.82
Apcin 25μM plus proTAME 2μM R04 exp177	2.26

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

tryptamine:oxygen oxidoreductase (deaminating) activity
aliphatic-amine oxidase activity
phenethylamine:oxygen oxidoreductase (deaminating) activity
aminoacetone:oxygen oxidoreductase(deaminating) activity
primary amine oxidase activity
quinone binding
catechol-containing compound metabolic process
catecholamine metabolic process
copper ion binding
amine metabolic process
electron transfer activity
phenol-containing compound metabolic process
xenobiotic metabolic process
electron transport chain
cellular response to xenobiotic stimulus
visual perception
sensory perception of light stimulus
response to xenobiotic stimulus
generation of precursor metabolites and energy
organic hydroxy compound metabolic process
oxidation-reduction process
sensory perception
nervous system process
system process