AP1AR [The Human Chemical-Genetic Interaction Map Project]

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======= AP1AR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AP1AR
  * **<color #00a2e8>Official Name</color>**: adaptor related protein complex 1 associated regulatory protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55435|55435]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q63HQ0|Q63HQ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AP1AR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AP1AR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610851|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus- end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo- lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle targeting, trans-Golgi to endosome|
|negative regulation of receptor recycling|
|AP-1 adaptor complex binding|
|negative regulation of substrate adhesion-dependent cell spreading|
|regulation of Arp2/3 complex-mediated actin nucleation|
|Golgi to endosome transport|
|regulation of receptor recycling|
|regulation of actin nucleation|
|kinesin binding|
|regulation of substrate adhesion-dependent cell spreading|
|negative regulation of cell-substrate adhesion|
|vesicle targeting, to, from or within Golgi|
|vesicle targeting|
|transport vesicle|
|negative regulation of cell morphogenesis involved in differentiation|
|post-Golgi vesicle-mediated transport|
|late endosome|
|cytosolic transport|
|regulation of actin filament polymerization|
|establishment of vesicle localization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|vesicle localization|
|regulation of cell-substrate adhesion|
|regulation of protein polymerization|
|early endosome|
|regulation of actin filament organization|
|endosome|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|negative regulation of cell development|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|regulation of cell morphogenesis|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|organelle localization|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|regulation of cell motility|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|regulation of organelle organization|
|negative regulation of signaling|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.75|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.78|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16690
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AP1AR Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>